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Thegold standard is the documentation of a cardiac arrhyth-mia during syncope, thereby establishing causation. The oxidized LDL cytotoxicity also manifested in the activation of apoptoticmechanisms. Thedisease often gets disseminated in immuno-compromised individuals and may be treated withoral or i.v. I often encourage my patients with these condi-tions to take them because I believe there is enough scientific evidence tosupport their use. However, nearlyone-third of patients still had severe pain at 23 months.In studies comparing vertebroplasty with conservativemanagement, vertebroplasty-treated patients consis-tently had significantly reduced pain scores, decreaseduse of analgesics, more rapid return to normal function,and lower rates of hospitalization, as compared with con-servatively treated patients (Diamond et al., 2006; Klazenet al., 2010; Wang et al., 2010). Pioglitazoneshould not be used during pregnancy.The DiabetesPrevention Programme (2005) has shown thatglitazones have the potential to delay progressionof prediabetics to overt type 2 DM.
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